WHO has carried out a six-year multidisciplinary work program to support Member States in strengthening their health system response to NCDs and to learn in the process. A regional study published in 2018 summarizes the lessons learnt in the WHO European region synthesizing the experience of middle and high income countries and diverse health system settings. The report shares 36 key messages in 9 key policy areas including governance, public health services, multi-profile primary care, regionalized specialist services, people-centerdness, health workforce, access to quality medicines, prioritized financing, and information solutions. The report is rich in country examples. A compendium of 22 good practices provide further contextualized detailes of successfully aligned systems approaches to NCDs.